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The pivotal trials leading to FDA approval demonstrated reductions in visceral adipose tissue of approximately 15 to 20% over 26 weeks in HIV lipodystrophy patients, with continued reduction at 52 weeks

However, the structurally modified version of the tetra-substituted peptide, Modified GRF 1-29, is considered to boast a longer half-life and has, therefore, been considered by researchers as a more viable compound for use during experimental research

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Adding a GHRP on top of that can lead to excessive GH exposure and increased side effects like water retention and numbness