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They know they need help, and they are tired of waiting for a system to catch up to the science
A Combination of Both If your goal is fat loss, muscle definition, and long-term health , the fastest and most sustainable approach is: Strength training at least 3x per week (prevents muscle loss, boosts metabolism)
A clinician may consider combination therapy when metformin alone does not meet individualized glucose goals, when weight is a major treatment factor, or when a GLP-1 receptor agonist fits the broader cardiometabolic plan
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Around 20% of each group discontinued the trial drugs during the study, and around 75% of those randomised to tirzepatide were on the 15 mg dose at 36 months
More serious but rare adverse effects include pancreatitis and gallbladder problems (such as cholelithiasis or cholecystitis)
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