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10.1089/ars.2021.0027 98 JuanC
By adopting the method, the self hydrophilic property of the ionic liquid inhibits the semaglutide H-His 1 -Aib 2 -Glu 3 -Gly 4 -Thr 5 -Phe 6 -Thr 7 -Ser 8 -Asp 9 -Val 10 -Ser 11 -Ser 12 -Tyr 13 -Leu 14 -Glu 15 The formation of hydrogen bonds in the molecule of the coupling difficult fragment avoids the formation of a beta-folding secondary structure, improves the coupling effect of the sequence, and greatly improves the purity and the synthesis yield of the final crude peptide
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