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Usually, 1 injection per week is recommended during the initial treatment course
Comparative Analysis of GLP-1 Receptor Agonists and Heartburn Incidence: Anderson, F., Zhou, B., & Patel, S
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Pyo, H.K., et al
A comparative analysis found that non-diabetic patients with obesity on tirzepatide had a 64% lower risk of developing new-onset gastroparesis compared to those on semaglutide
Serious side effects of the medication include the following: Allergic or hypersensitivity reaction Severe gastrointestinal issues Changes in mood and behavior Pancreatitis Liver problems Low blood sugar levels (hypoglycemia) Cardiac arrhythmias Suicidal ideation Major depressive disorder No adverse event of hypoglycemia or thyroid cancer was reported in Phase II trials, and 7% of retatrutide participants had skin sensitivity, compared to 1% on placebo, but these cases were not serious
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