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Endnotes: The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and modifications) without initiating prohibited weight management treatments (and glycemic rescue therapy for glycemic endpoints only)

Those with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use this medication

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Flux through the glycolytic pathway is tightly controlled through regulation of glycolytic enzyme activity by allosteric modulation, post-translational modifications as well as transcriptional control