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For the millions of years before we began to sharpen spears, mill grains, or boil sugarcane, our entire physiology is presumed to have evolved in the context of eating what our great ape cousins did: a diet comprised of leaves, roots, fruits, and nuts

Chin J Integr Med 2013

The mechanism is thought to involve binding of the peptide C terminus to the receptor extracellular domain, followed by insertion of the peptide N terminus into the pocket formed by the transmembrane helices and extracellular loops, instigating receptor activation and signalling 19

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