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It might start local, but then it goes into the bloodstream and it becomes systemic

"MariTide delivered strong efficacy, including sustained weight loss without a plateau in the 52-week phase 2 study and meaningful improvements in cardiometabolic risk factors, representing a defining advance for the obesity field," says Jay Bradner, the executive vice president for research and development at Amgen

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The resulting RNA was eluted with 45 l H 2 O and concentration as well as purity was measured with a NanoDrop ND-1000 spectrophotometer (NanoDrop, Wilmington, Delaware, USA)

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