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Clinically important weight reduction requires a combination of a reduced-calorie diet and patient-centered physical-activity interventions, which may be challenging to adhere to but have been shown to improve patient-reported outcomes related to pain

It was as if the festival was waiting for someone like the 29-year-old Austrian, who bought a new beige linen suit for the occasion, to take advantage of a hype machine 30 years in the making

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Reducing or avoiding them may help ease symptoms

If you feel fine on the starter dose, your clinician may discuss a cautious increase after about four weeks