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Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation

Regional and whole body hyperthermia can cause nausea, diarrhea, vomiting, and, less frequently, problems with blood vessels and the heart (ACS 2013b

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If a selective amylin agonist can hold roughly 20% at the top dose while producing placebo-like adverse-event rates at lower doses, the interesting downstream question becomes combination and sequencing, not replacement