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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
Presented for research literature review only Rogerson KS et al
Peana M, Pelucelli A, Chasapis CT, et al
This information is for educational purposes onlynot medical advice
This is speculative, but it is grounded in the direction current research is heading
However, clinical practitioners often recommend a "start low and go slow" approach, particularly for patients with severe chronic illness who may be highly sensitive to new supplements or prone to detoxification reactions (Herxheimer reactions)
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