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Description

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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects

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AOD-9604 and GLP-1 agonists like Semaglutide or Tirzepatide work through fundamentally different mechanisms with very different efficacy profiles

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