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Analysis of TMAO, L-carnitine, -BB, and TMA in Phase II samples followed previously described methods (25, 46)

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Long-term hyperglycemia can contribute to persistent disturbances in glutamatergic signaling and neural damage in the medial prefrontal cortex, contributing to depressive behaviors [91]

In the 2025 study mentioned earlier, women receiving the combination therapy experienced an average weight loss of 6.09 kg (about 13.4 lbs) over 16 weeks, compared to 2.25 kg (approximately 5.0 lbs) in the metformin-only group

Post-treatment side effects

Berg S, et al