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N 1 -acetylspermine and N 1 -acetylspermidine are converted to spermidine and putrescine, respectively, by polyamine oxidase (encoded by the PAOX gene) along with the production of H 2 O 2 and 3-acetylaminopropanal (3Ac-AP or 3-AAP)

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Unfortunately, in some cases, certain treatments can lead to even more complications